Search results for "Parkinsonin tauti"

Attenuated beta rebound to proprioceptive afferent feedback in Parkinson's disease.

2018

AbstractMotor symptoms are defining traits in the diagnosis of Parkinson’s disease (PD). A crucial component in motor function and control of movements is the integration of efferent signals from the motor network to the peripheral motor system, and afferent proprioceptive sensory feedback. Previous studies have indicated abnormal movement-related cortical oscillatory activity in PD, but the role of the proprioceptive afference on abnormal oscillatory activity in PD has not been elucidated. In the present study, we examine the role of proprioception by studying the cortical processing of proprioceptive stimulation in PD patients, ON/OFF levodopa medication, as compared to that of healthy co…

Structure-Activity Relationship Analysis of 3-Phenylcoumarin-Based Monoamine Oxidase B Inhibitors

2018

Monoamine oxidase B (MAO-B) catalyzes deamination of monoamines such as neurotransmitters dopamine and norepinephrine. Accordingly, small-molecule MAO-B inhibitors potentially alleviate the symptoms of dopamine-linked neuropathologies such as depression or Parkinson's disease. Coumarin with a functionalized 3-phenyl ring system is a promising scaffold for building potent MAO-B inhibitors. Here, a vast set of 3-phenylcoumarin derivatives was designed using virtual combinatorial chemistry or rationally de novo and synthesized using microwave chemistry. The derivatives inhibited the MAO-B at 100 nM−1 μM. The IC50 value of the most potent derivative 1 was 56 nM. A docking-based structure-activi…

Life-Space Mobility in Parkinson's Disease: Associations with Motor and Non-Motor Symptoms.

2019

Background To describe life-space mobility and explore associations of motor and non-motor symptoms with life-space mobility in people with Parkinson’s disease (PD). Methods About 164 community-dwelling persons with PD (mean age 71.6 years, 64.6% men) received a postal survey and a subsequent home visit. Motor assessments included perceived walking difficulties (Walk-12G), mobility (Timed Up and Go test), motor symptoms (UPDRS-III), and freezing of gait (item 3, FOG-Qsa). Non-motor symptoms included depressive symptoms (GDS-15), pain, fatigue (NHP-EN), and global cognition (MoCA). Life-space mobility was assessed with the life-space assessment (LSA). Calculations included composite score (r…

Music therapy in Parkinson's disease

2014

Cortical beta burst dynamics are altered in Parkinson's disease but normalized by deep brain stimulation

2022

Funding Information: Amande Pauls was supported by a personal grant from the University of Helsinki . Olesia Korsun was supported by the Päivikki and Sakari Sohlberg Foundation , the Orion Research Foundation , the Finnish Parkinson Foundation and the Finnish Brain Foundation . Mia Liljeström was supported by the Swedish Cultural Foundation in Finland , the Päivikki and Sakari Sohlberg Foundation , and the Finnish Cultural Foundation . Eero Pekkonen was supported by Finnish Government research funding ( TYH- fund ). Hanna Renvall was supported by the Academy of Finland (grant number 321460 ) and Paulo Foundation. Publisher Copyright: © 2022 Exaggerated subthalamic beta oscillatory activity …

Parkinson's disease and segmental coordination during modified figure of eight walking turning task

2016

Turning while walking is problematic for individuals with Parkinson’s disease (PD). We hypothesized there would be instability and turning difficulty for the PD subjects while performing a complex motor skill task of the modified figure of eight (MFE) walking task. There were 26 subjects (10 males and 16 females) with clinical diagnosis of “idiopathic” PD and undergoing L-dopa treatment participating in this study. The PD subjects performed the clinical balance modified figure of eight (MFE) test. The 3-D positions of the head, trunk and pelvis were recorded and analyzed. The angular displacement and angular velocity of the head, trunk and pelvis were calculated. Counter-clockwise and clock…

Nuclear microscopy : development and applications in atherosclerosis, Parkinson's disease and matherials physics

2007

Therapeutic Benefits of Music-Based Synchronous Finger Tapping In Parkinson’s Disease – an fNIRS Study Protocol for Randomized Controlled Trial in Da…

2020

Abstract Background: Music therapy improves neuronal activity and connectivity of healthy persons and patients with clinical symptoms of neurological diseases like Parkinson’s disease, Alzheimer’s Disease, and Major Depression. Despite the plethora of publications that have reported the positive effects of music interventions, little is known about how music improves neuronal activity and connectivity in afflicted patients.Methods: For patients suffering from Parkinson’s disease (PD), we propose a daily 25-minute music-based synchronous finger tapping (SFT) intervention for 8-weeks. Eligible participants with PD are split into two groups: an intervention group and a control arm. In addition…

Development of a Parkinson’s disease specific falls questionnaire

2020

Abstract Background Falls are a major health burden for older adults with Parkinson’s disease (PD), but there is currently no reliable questionnaire to capture the circumstances and consequences of falls in older adults with PD. This study aimed to develop a PD-specific falls questionnaire and to evaluate its test-retest reliability in older adults with PD. Methods A novel PD-specific falls questionnaire (PDF-Q) was developed in two modes (online and paper-based version) and used to assess falls and near-falls events over the past 12-months. Questions were agreed upon by an expert group, with the domains based on previous falls-related questionnaires. The questions included the number and c…

Uusien alatyyppivalikoivien monoamiinioksidaasi B -inhibiittoreiden suunnittelu

2015

MAO-B (MAO-B) on yksi amiinien hapetuksesta vastaavista entsyymeistä. Se vaikuttaa esimerkiksi aivoissa hermosolujen toimintaan säätelemällä hermovälittäjäaineiden pitoisuutta solun sisällä. MAO-B-inhibiittoreilla voidaan estää kyseisen entsyymin toimintaa ja täten liiallista amiinien hajotusta, joka voi johtaa muun muassa hermostosairauksiin. Tässä tutkimuksessa pyrittiin suunnittelemaan ihmisen MAO-B:hen sitoutuvien 3-fenyylikumariineja. Tutkimus jakautui kahteen osaan. Ensimmäisessä osassa tietokonemallinnuksella tietokantoja seulomalla ja löydettyjä molekyylejä telakoimalla löytyi seitsemän uutta molekyyliä, jotka sisälsivät paljon rengasrakenteita ja fluoriryhmiä. Molekyylit vuorovaiku…